Determination of the thermodynamic solubility and the affinity (binding) constants of Carbamazepine, Danazol and Albendazole in Hydroxypropyl Beta Cyclodextrin (KLEPTOSE® HPB) solutions. The unique cyclic structure of Hydroxypropyl Beta - Cyclodextrin (HPBCD) enables the formation of host-guest complexes by accommodating a wide variety of drug molecules inside its hydrophobic cavity resulting in the inclusion complexes, where lipophilic compounds are noncovalently bound within the cavity.
The influence of HPBCD on the solubility of BSC II compounds is a valuable tool to evaluate the possibility of a parenteral alternative to drugs which are commercially available as a solid dosage form.