The study assesses the suitability of excipients and superdisintegrants for developing an ODT platform using conventional and non-conventional tests. Orally Disintegrating Tablets (ODTs) are fast gaining popularity as a novel oral drug delivery system. They demonstrate unique advantages by addressing patient compliance issues with pediatric, geriatric and uncooperative patients unable to swallow tablets. They also allow administration of medication without any need for water.
To-date a variety of ODTs with their own claim of advantages have been developed using technologies ranging from as simple as wet granulation or direct compression to as complex lyophilization. No single excipient can fulfill the requirements of all ODT formulations. The study may ultimately help in selection of the best possible combination of excipient and superdisintegrant for developing an optimal ODT formulation.
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