This poster studies the Influence of Beta-Cyclodextrin Side Chain Substitutions on the Complexation Efficiency of a Model BCS Class II Compound. The Biopharmaceutics Classification System (BCS) predicts oral drug absorption based on the chemical’s aqueous solubility and intrinsic permeability through the gastrointestinal mucosa. Drugs that are highly permeable but have limited water solubility are considered BCS class II compounds.
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To improve aqueous solubility and thus the therapeutic effectiveness of such compounds, a number of formulation strategies have been employed.
- Cyclodextrins are cyclic oligosaccharides with a bucket-like structure having a hydrophobic internal cavity and a hydrophilic exterior. This unique structure allows for the formation of inclusion complexes, where lipophilic compounds are non-covalently bound within the cavity.
- Cyclodextrins have been widely used in oral and parenteral drug delivery systems to improve the aqueous solubility and chemical stability of drugs. Topical applications of cyclodextrins have also been investigated.
- Cyclodextrins differ by the number of glucose units forming the ring structure as well as chemical substitutions on the exterior of the ‘bucket’. The influence of side chain substitutions of the cyclodextrin on the solubility of Ibuprofen, a BSC II model compound is essential to understand the complexation process.