Cellulosic polymers such as HPMC are widely used in film coating of these tablets, but suffer from drawbacks such as:
- Strong unwanted taste/odor and yellowish color to the solution
- Difficulty in solubilization due to lumping and foam formation
- “Bearding” on spray nozzles causing frequent production stops for cleaning
- High coating cost per tablet due to longer coating times
HPMC has a strong tendency to interact with antioxidant polyphenolic actives, resulting in formation of a sticky gel, which significantly increases tablet disintegration time (DT). A novel pregelatinized, hydroxypropyl starch polymer (LYCOAT®), ensures minimal interaction with polyphenolic actives and does not prolong DT of coated tablets.