Étude de cas: Évaluation d'un nouveau polymère d'amidon modifié en tant qu'excipient prêt à l'emploi
This poster presents an evaluation of LYCOAT® RS720 and its advantages over the Oral Disintegrating Film market. In recent years ODF became a very popular drug delivery system due to the fact that it can deliver the drug directly to the systemic circulation (avoiding the first pass metabolism). It enhances drug efficacy by lowering the dose and improving the onset of action and consequently patient compliance.
Roquette
To get the required rheological properties several hydrosoluble polymers and plasticizers are generally selected. Using only one polymer, a non-GMO pregelatinized hydroxypropyl pea starch, LYCOAT® RS720, we obtained the desired mechanical, rheological, and functional properties. Using the film casting technique (at room temperature) we obtained an ODF construct having good drug uniformity and dissolution performance.