Mannitol selected as the best filler to further optimize physical stability, mouthfeel and fast disintegration of type-C polymethacrylate-containing Fast Melting Tablets. The object of the present work was to design and develop a placebo FMT (Fast Melting Tablets) formulation able to disintegrate in less than 20 seconds and characterized by acceptable technological properties (friability and crushing strength).

The first aim of this study was to access the influence of various direct-compression excipients on the disintegration performance and technological properties of the tablets. The second aim was to study the influence of the compression force on the performance and on the technological properties (friability, crushing strength, disintegration time) of these drug delivery systems.