Oral and vaginal routes have low bioavailability and, in addition oral route has a limited usefulness because of its short half-life and extensive degradation after absorption. Therefore the injection route should be the preferred choice, but the oily solution and the water suspension allow only intramuscular administration with a considerable pain during the treatment. This encourages the research of new water soluble injectable pharmaceutical forms with increased patient compliance.
Case study: KLEPTOSE® BIOPHARMA, alternative fonctionnelle potentielle aux surfactants dans les formulations biologiquesKLEPTOSE® BioPharma (hydroxypropyl beta cyclodextrin) represents a promising alternative to surfactants commonly used within biologic formulations, such as polysorbates.
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